Recombinant Human APN Protein (C-6His),APN

产品说明(Description)

Recombinant Human Aminopeptidase N is produced by our Mammalian expression system and the target gene encoding Lys69­Lys967 is expressed with a 6His tag at the C-terminus.

Accession #: P15144

Known as: Aminopeptidase N; ANPEP; AP-M; APN; AP-N; CD13 antigen; CD13; CD13APN; PEPN; PEPNhAPN

制剂(Formulation)

Supplied as a 0.2 μm filtered solution of PBS, 5% Trehalose, pH 7.4.

质量控制(Quality Control)

Purity:            Greater than 95% as determined by reducing SDS-PAGE.

Endotoxin:     NA

运输(Shipping)

The product is shipped on dry ice/polar packs. 

Upon receipt, store it immediately at the temperature listed below.

保存(Storage)

Store at ≤-70°C, stable for 6 months after receipt. 

Store at ≤-70°C, stable for 3 months under sterile conditions after opening. 

Please minimize freeze-thaw cycles.

背景(Background)

ANPEP gene encodes aminopeptidase N (APN)  also known as microsomal aminopeptiase, alanyl aminopeptidase, aminopeptidase M, CD13, or membrane protein p161, is a member of the peptidase M1 family. Widely expressed in many cells, tissues and species, APN cleaves the N-terminal amino acids from bioactive peptides, leading to their inactivation or degradation. Probably plays a role in regulating growth and differentiation of early B-lineage cells. It also may play a role in the catabolic pathway of the renin-angiotensin system. It degrades vasoconstricting angiotensin II into angiotensin III and therefore helps to regulate blood pressure.

电泳(SDS-PAGE)

参考文献（Reference)

Adiponectin alleviates the symptoms of ischemic renal disease by inhibiting renal cell apoptosis[J]. Xiaotong Zheng. et al. Life Sciences. 2020.